Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study.

ABSTRACT:

Aims/hypothesis

We examined the association of attainment of diabetes remission in the context of a 12 year intensive lifestyle intervention with subsequent incidence of chronic kidney disease (CKD) and CVD.

Methods

The Look AHEAD study was a multi-centre RCT comparing the effect of a 12 year intensive lifestyle intervention with that of diabetes support and education on CVD and other long-term health conditions. We compared the incidence of CVD and CKD among 4402 and 4132 participants, respectively, based on achievement and duration of diabetes remission. Participants were 58% female, and had a mean age of 59 years, a duration of diabetes of 6 year and BMI of 35.8 kg/m². We applied an epidemiological definition of remission: taking no diabetes medications and hav

SUBMITTER: Gregg EW 

PROVIDER: S-EPMC10844408 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature