Causal association between genetically predicted circulating immune cell counts and frailty: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Despite the recognized link between immune responses and frailty, the association between immune cell counts and frailty based on previous observational studies remains disputed, with uncertain causal nexus. This study aimed to elucidate causal association between genetically predicted circulating immune cell counts and frailty.

Methods

We conducted the two-sample Mendelian randomization (MR) study with independent genetic variants associated with six immune cell subtype counts from genome-wide association studies in 563,946 European individuals. Frailty summary data, assessed via frailty index (FI), was obtained from study comprising 175,226 subjects. Univariate MR, reverse MR and multivariate MR were conducted to comprehensive investigate the association between

SUBMITTER: Guo XG 

PROVIDER: S-EPMC10844461 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature