Ontology highlight
ABSTRACT:
SUBMITTER: Yin L
PROVIDER: S-EPMC10844523 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Life science alliance 20240205 4
Radiation therapy (RT) is one of the most commonly used anticancer therapies. However, the landscape of cellular response to irradiation, especially to a single high-dose irradiation, remains largely unknown. In this study, we performed a whole-genome CRISPR loss-of-function screen and revealed temporal inherent and acquired responses to RT. Specifically, we found that loss of the IL1R1 pathway led to cellular resistance to RT. This is in part because of the involvement of radiation-induced IL1R ...[more]