Regional decreases of cortical thickness in major depressive disorder and their correlation with illness duration: a case-control study.

ABSTRACT:

Background

Alterations in brain structure and function in major depressive disorder (MDD) have been identified in a number of studies, but findings regarding cortical thickness were various and inconsistent. Our current study aims to explore the differences in cortical thickness between individuals with MDD and healthy controls (HC) in a Chinese population.

Methods

We investigated T1-weighted brain magnetic resonance imaging data from 61 participants (31 MDD and 30 HC). The cortical thickness between the two groups and analyzed correlations between cortical thickness and demographic variables in the MDD group for regions with significant between-group differences were conducted.

Results

Compared with the HC group, patients with MDD had significantly decreased cortical

SUBMITTER: Wang F 

PROVIDER: S-EPMC10844537 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature