Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals.

ABSTRACT: Bidirectional interactions between the immune system and the gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer and autoimmunity, and efficacy of immunomodulatory therapies, have been linked to microbiome variation. Although COVID-19 infection has been shown to cause microbial dysbiosis, it remains understudied whether the inflammatory response associated with vaccination also impacts the microbiota. Here, we investigate the temporal impact of COVID-19 vaccination on the gut microbiome in healthy and immuno-compromised individuals; the latter included patients with primary immunodeficiency and cancer patients on immunomodulating therapies. We find that the gut microbiome remained remarkably stable post-vaccination irrespective

SUBMITTER: Boston RH 

PROVIDER: S-EPMC10844540 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature