Establishment and comparison of different procedures for modeling intrauterine adhesion in rats: A preliminary study.

ABSTRACT: The establishment of a stable animal model for intrauterine adhesion (IUA) can significantly enhance research on the pathogenesis and pathological changes of this disease, as well as on the development of innovative therapeutic approaches. In this study, three different modeling methods, including phenol mucilage combined mechanical scraping, ethanol combined mechanical scraping and ethanol modeling alone were designed. The morphological characteristics of the models were evaluated. The underlying mechanisms and fertility capacity of the ethanol modeling group were analyzed and compared to those of the sham surgery group. All three methods resulted in severe intrauterine adhesions, with ethanol being identified as a reliable modeling agent and was subsequently subjected to further evaluati

SUBMITTER: Liu PC 

PROVIDER: S-EPMC10844578 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature