Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons.

ABSTRACT:

Introduction

Patient-derived induced pluripotent stem cells (iPSCs) have been widely used as disease models to test new therapeutic strategies. Moreover, the regenerative potential of stem cells can be improved with the use of biologically active compounds. Our study was designed to explore the effect of honokiol, a small polyphenol molecule extracted from Magnolia officinalis, on the survival and culture time of iPSC-derived neurons from a sporadic Alzheimer's disease (AD) patient. This study aimed to generate iPSCs from peripheral blood mononuclear cells (PBMCs) of an AD patient using episomal plasmids with a nucleofector system and differentiate them into neurons. These iPSC-derived neurons were used to investigate the effect of honokiol extracted from M. officinalis</

SUBMITTER: Le DTT 

PROVIDER: S-EPMC10844589 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature