Software BreastAnalyser for the semi-automatic analysis of breast cancer immunohistochemical images.

ABSTRACT: Breast cancer is the most diagnosed cancer worldwide and represents the fifth cause of cancer mortality globally. It is a highly heterogeneous disease, that comprises various molecular subtypes, often diagnosed by immunohistochemistry. This technique is widely employed in basic, translational and pathological anatomy research, where it can support the oncological diagnosis, therapeutic decisions and biomarker discovery. Nevertheless, its evaluation is often qualitative, raising the need for accurate quantitation methodologies. We present the software BreastAnalyser, a valuable and reliable tool to automatically measure the area of 3,3'-diaminobenzidine tetrahydrocholoride (DAB)-brown-stained proteins detected by immunohistochemistry. BreastAnalyser also automatically counts cell nuclei and

SUBMITTER: Rodriguez-Candela Mateos M 

PROVIDER: S-EPMC10844656 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature