Gastrodin alleviates premature senescence of vascular endothelial cells by enhancing the Nrf2/HO-1 signalling pathway.

ABSTRACT: Endothelial dysfunction is an independent risk factor for stroke. The dysfunction of endothelial cells (EC) is closely concerned with EC senescence. Gastrodin (GAS) is an organic compound extracted from the dried root mass of the Orchidaceae plant Gastrodiae gastrodiae. It is used clinically to treat diseases such as vertebrobasilar insufficiency, vestibular neuronitis and vertigo. In the present study, we used hydrogen peroxide (H₂ O₂ )-induced human umbilical vein endothelial cells (HUVECs) to establish an in vitro EC senescence model and to investigate the role and mechanism of GAS in EC senescence. It's found that H₂ O₂ -treated HUVECs increased the proportion of senescence-associated β-galactosidase (SA β-gal) positive cells and the relative

SUBMITTER: Tong P 

PROVIDER: S-EPMC10844697 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature