Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are being used to eliminate it. A.baumannii has been the cause of death in immune compromised patients in hospitals. Hence it is the urgent need of time to find potential inhibitors for this bacterium to cease its virulence and affect its survival inside host organisms. The Dihydrofolate reductase enzyme, which is an important biocatalyst in the conversion of Dihydrofolate to Tetrahydrofolate, is an important drug target protein. In the present study high throughput screening is used to identify the inhibitors of this enzyme. The prioritized l

SUBMITTER: Bhati SK 

PROVIDER: S-EPMC10844809 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature