Identification of AgRP cells in the murine hindbrain that drive feeding.

ABSTRACT:

Objective

The central melanocortin system is essential for the regulation of food intake and body weight. Agouti-related protein (AgRP) is the sole orexigenic component of the central melanocortin system and is conserved across mammalian species. AgRP is currently known to be expressed exclusively in the mediobasal hypothalamus, and hypothalamic AgRP-expressing neurons are essential for feeding. Here we characterized a previously unknown population of AgRP cells in the mouse hindbrain.

Methods

Expression of AgRP in the hindbrain was investigated using gene expression analysis, single-cell RNA sequencing, immunofluorescent analysis and multiple transgenic mice with reporter expressions. Activation of AgRP neurons was achieved by Designer Receptors Exclusively Activated by Des

SUBMITTER: Bachor TP 

PROVIDER: S-EPMC10844855 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature