Atomic-scale structure of interfacial water on gel and liquid phase lipid membranes.

ABSTRACT: Hydration of biological membranes is essential to a wide range of biological processes. In particular, it is intrinsically linked to lipid thermodynamic properties, which in turn influence key cell functions such as ion permeation and protein mobility. Experimental and theoretical studies of the surface of biomembranes have revealed the presence of an interfacial repulsive force, which has been linked to hydration or steric effects. Here, we directly characterise the atomic-scale structure of water near supported lipid membranes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine in their gel and liquid phase through three-dimensional atomic force microscopy (3D AFM). First, we demonstrate the ability to probe the morphology of interfacial water of lipid bilayers in both phases with sub-

SUBMITTER: Benaglia S 

PROVIDER: S-EPMC10845012 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature