Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia.

ABSTRACT:

Importance

A healthy lifestyle is associated with better cognitive functioning in older adults, but whether this association is independent of the accumulation of dementia-related pathologies in the brain is uncertain.

Objective

To determine the role of postmortem brain pathology, including β-amyloid load, phosphorylated tau tangles, cerebrovascular pathology, and other brain pathologies, in the association between lifestyle and cognition proximate to death.

Design, setting, and participants

This cohort study used data from the Rush Memory and Aging Project, a longitudinal clinical-pathologic study with autopsy data from 1997 to 2022 and up to 24 years of follow-up. Participants included 754 deceased individuals with data on lifestyle factors, cognitive testing proxim

SUBMITTER: Dhana K 

PROVIDER: S-EPMC10845037 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature