Adolescents' pain-related ontogeny shares a neural basis with adults' chronic pain in basothalamo-cortical organization.

ABSTRACT: During late adolescence, the brain undergoes ontogenic organization altering subcortical-cortical circuitry. This includes regions implicated in pain chronicity, and thus alterations in the adolescent ontogenic organization could predispose to pain chronicity in adulthood - however, evidence is lacking. Using resting-state functional magnetic resonance imaging from a large European longitudinal adolescent cohort and an adult cohort with and without chronic pain, we examined links between painful symptoms and brain connectivity. During late adolescence, thalamo-, caudate-, and red nucleus-cortical connectivity were positively and subthalamo-cortical connectivity negatively associated with painful symptoms. Thalamo-cortical connectivity, but also subthalamo-cortical connectivity, was increas

SUBMITTER: Heukamp NJ 

PROVIDER: S-EPMC10845062 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature