Pd-Catalyzed [4 + 1] Annulation Strategy to Functionalized 4-Methyleneproline Derivatives.

ABSTRACT: A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization of a proline-based derivative.

SUBMITTER: Han J 

PROVIDER: S-EPMC10845110 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature