Synergistic Effect of Brevetoxin BTX-3 and Ciguatoxin CTX3C in Human Voltage-Gated Na_v1.6 Sodium Channels.

ABSTRACT: Emerging marine biotoxins such as ciguatoxins and brevetoxins have been widely and independently studied as food pollutants. Their maximum levels in food components were set without considering their possible synergistic effects as consequence of their coexistence in seafood and their action at the same cellular target. The absolute lack of data and regulations of the possible combined effects that both marine biotoxins may have raised the need to analyze their direct in vitro effects using electrophysiology techniques. The results presented in this study indicate that ciguatoxins and brevetoxins had a synergistic effect on human Na_v1.6 voltage-gated sodium channels by hyperpolarizing their activation and inactivation states. The results presented here indicate that breve

SUBMITTER: Raposo-Garcia S 

PROVIDER: S-EPMC10845145 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature