Increased resected lymph node stations improved survival of esophageal squamous cell carcinoma.

ABSTRACT:

Background

Neoadjuvant chemoradiotherapy (nCRT) and surgery have been recommended as the standard treatments for locally advanced esophageal squamous cell carcinoma (ESCC). In addition, nodal metastases decreased in frequency and changed in distribution after neoadjuvant therapy. This study aimed to examine the optimal strategy for lymph node dissection (LND) in patients with ESCC who underwent nCRT.

Methods

The hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS) were calculated using the Cox proportional hazard model. To determine the minimal number of LNDs (n-LNS) or least station of LNDs (e-LNS), the Chow test was used.

Results

In total, 333 patients were included. The estimated cut-off values for e-LNS and n-LNS were 9 and 15, respectivel

SUBMITTER: Lu RD 

PROVIDER: S-EPMC10845591 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature