Evaluation of the association between TNF-α-1031 T/C polymorphism with oral lichen planus disease.

ABSTRACT:

Background

Oral lichen planus (OLP) is a T-cell-mediated autoimmune disease that affects the epithelial cells of the oral cavity. This study was performed to investigate any possible relationship between - 1031(T/C) polymorphism (rs1799964) of the tumor necrosis factor α (TNF-α) gene with the risk and severity of oral lichen planus (OLP) disease among an Iranian population.

Method

Saliva samples were collected from 100 patients with OLP and a similar number of healthy controls (age and sex-matched). Then, DNA was extracted from the collected samples for genotyping TNF-α-1031 T/C polymorphism using the PCR-CTPP method. The results were assessed using SPSS software.

Results

The findings revealed a significantly higher prevalence of the C allele in OLP patients (53%) com

SUBMITTER: Marabi MH 

PROVIDER: S-EPMC10845614 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature