Spatial and single-cell analyses uncover links between ALKBH1 and tumor-associated macrophages in gastric cancer.

ABSTRACT:

Background

AlkB homolog 1, histone H2A dioxygenase (ALKBH1), a crucial enzyme involved in RNA demethylation in humans, plays a significant role in various cellular processes. While its role in tumor progression is well-established, its specific contribution to stomach adenocarcinoma (STAD) remains elusive. This study seeks to explore the clinical and pathological relevance of ALKBH1, its impact on the tumor immune microenvironment, and its potential for precision oncology in STAD.

Methods

We adopted a comprehensive multi-omics approach to identify ALKBH1 as an potential diagnostic biomarker for STAD, demonstrating its association with advanced clinical stages and reduced overall survival rates. Our analysis involved the utilization of publicly available datasets from GEO and

SUBMITTER: Chang R 

PROVIDER: S-EPMC10845659 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature