Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.

ABSTRACT:

Background

Pericytes are a vital component of the blood-brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic inflammation and energy metabolism in obesity. The present study investigated the impact of pericytes on the pathophysiology of obesity by focusing on platelet-derived growth factor (PDGF) signaling, which regulates pericyte functions.

Methods

Tamoxifen-inducible systemic conditional PDGF receptor β knockout mice (Pdgfrb^∆SYS-KO) and Calcium/calmodulin-dependent protein kinase type IIa (CaMKIIa)-positive neuron-specific PDGF receptor β knockout mice (Pdgfrb^∆CaMKII-KO) were fed a high-fat diet, and metabolic phenotypes before and 3 to 4 we

SUBMITTER: Okekawa A 

PROVIDER: S-EPMC10845801 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature