Marital status and genetic liability independently predict coronary heart disease incidence.

ABSTRACT:

Aims

Married individuals have a lower coronary heart disease (CHD) risk than non-married, but the mechanisms behind this are not fully understood. We analyzed whether genetic liability to CHD may affect these associations.

Methods

Marital status, a polygenic score of CHD (PGS-CHD), and other risk factors for CHD were measured from 35,444 participants (53% female) in Finnish population-based surveys conducted between 1992 and 2012. During the register-based follow-up until 2020, there were 2439 fatal and non-fatal incident CHD cases. The data were analyzed using linear and Cox regression models.

Results

Divorced and cohabiting men and women had a higher genetic risk of CHD than married individuals, but the difference was very small (0.023-0.058 standard deviation of PG

SUBMITTER: Silventoinen K 

PROVIDER: S-EPMC10845822 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature