Daptomycin avoids drug resistance mediated by the BceAB transporter in Streptococcus pneumoniae.

ABSTRACT: Drug-resistant bacteria are a serious threat to human health as antibiotics are gradually losing their clinical efficacy. Comprehending the mechanism of action of antimicrobials and their resistance mechanisms plays a key role in developing new agents to fight antimicrobial resistance. The lipopeptide daptomycin is an antibiotic that selectively disrupts Gram-positive bacterial membranes, thereby showing slower resistance development than many classical drugs. Consequently, it is often used as a last resort antibiotic to preserve its use as one of the least potent antibiotics at our disposal. The mode of action of daptomycin has been debated but was recently found to involve the formation of a tripartite complex between undecaprenyl precursors of cell wall biosynthesis and the anionic phos

SUBMITTER: Faure A 

PROVIDER: S-EPMC10846014 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature