Major urinary protein (Mup) gene family deletion drives sex-specific alterations in the house-mouse gut microbiota.

ABSTRACT: The gut microbiota is shaped by host metabolism. In house mice (Mus musculus), major urinary protein (MUP) pheromone production represents a considerable energy investment, particularly in sexually mature males. Deletion of the Mup gene family shifts mouse metabolism toward an anabolic state, marked by lipogenesis, lipid accumulation, and body mass increases. Given the metabolic implications of MUPs, they may also influence the gut microbiota. Here, we investigated the effect of a deletion of the Mup gene family on the gut microbiota of sexually mature mice. Shotgun metagenomics revealed distinct taxonomic and functional profiles between wild-type and knockout males but not females. Deletion of the Mup gene cluster significantly reduced diversity in microbial fa

SUBMITTER: Real MVF 

PROVIDER: S-EPMC10846032 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature