Oral microbiome associated with differential ratios of Porphyromonas gingivalis and Streptococcus cristatus.

ABSTRACT: Periodontitis has recently been defined as a dysbiotic disease caused by an imbalanced oral microbiota. The transition from commensal microbial communities to periodontitis-associated ones requires colonization by specific pathogens, including Porphyromonas gingivalis. We previously reported an antagonistic relationship between Streptococcus cristatus and P. gingivalis. To determine the role of S. cristatus in altering the interactions of P. gingivalis with other oral bacteria in a complex context, we collected dental plaque samples from patients with periodontitis and assigned them to two groups based on the ratios of S. cristatus and P. gingivalis. We then characterized the microbial profiles of the dental plaque samples using shotgun meta

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10846039 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature