Temporal development and potential interactions between the gut microbiome and resistome in early childhood.

ABSTRACT: Antimicrobial resistance-associated infections have become a major threat to global health. The gut microbiome serves as a major reservoir of bacteria with antibiotic resistance genes; whereas, the temporal development of gut resistome during early childhood and the factors influencing it remain unclear. Moreover, the potential interactions between gut microbiome and resistome still need to be further explored. In this study, we found that antibiotic treatment led to destabilization of the gut microbiome and resistome structural communities, exhibiting a greater impact on the resistome than on the microbiome. The composition of the gut resistome at various developmental stages was influenced by the abundance and richness of different core microbes. First exposure to antibiotics led to a dr

SUBMITTER: Zhao L 

PROVIDER: S-EPMC10846076 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature