Biological characterization and genomic analysis of a novel methicillin-resistant Staphylococcus aureus phage, SauPS-28.

ABSTRACT: Staphylococcus aureus, a representative gram-positive bacterium, is a common infectious pathogen widely present in the natural environment. The increasing application of antibiotics is witnessing an increment in the number of clinically resistant strains (such as methicillin-resistant S. aureus [MRSA]), which has posed a great challenge to antimicrobial therapy. In this study, a novel MRSA phage, SauPS-28, was isolated from the lake water of the Guangxi Zhuang Autonomous Region. This phage has an incubation period of approximately 30 min, a lysis period of approximately 40 min, and a burst size of approximately 25 PFU/cell. The isolated phage exhibited good biological stability at a pH range of 6.0-9.0 and temperature range of 4°C-37°C. In addition, the identification of an e

SUBMITTER: Zhao P 

PROVIDER: S-EPMC10846126 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature