Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in critical care patients.

ABSTRACT: Colonization with multidrug-resistant Escherichia coli strains causes a substantial health burden in hospitalized patients. We performed a longitudinal genomics study to investigate the colonization of resistant E. coli strains in critically ill patients and to identify evolutionary changes and strain replacement events within patients. Patients were admitted to the intensive care unit and hematology wards at a major hospital in Lebanon. Perianal swabs were collected from participants on admission and during hospitalization, which were screened for extended-spectrum beta-lactamases and carbapenem-resistant Enterobacterales. We performed whole-genome sequencing and analysis on E. coli strains isolated from patients at multiple time points. The E. coli isolates we

SUBMITTER: El Chaar M 

PROVIDER: S-EPMC10846182 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature