Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.

ABSTRACT: While numerous health-beneficial interactions between host and microbiota have been identified, there is still a lack of targeted approaches for modulating these interactions. Thus, we here identify precision prebiotics that specifically modulate the abundance of a microbiome member species of interest. In the first step, we show that defining precision prebiotics by compounds that are only taken up by the target species but no other species in a community is usually not possible due to overlapping metabolic niches. Subsequently, we use metabolic modeling to identify precision prebiotics for a two-member Caenorhabditis elegans microbiome community comprising the immune-protective target species Pseudomonas lurida MYb11 and the persistent colonizer Ochrobactrum vermis M

SUBMITTER: Marinos G 

PROVIDER: S-EPMC10846184 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature