Microbial, proteomic, and metabolomic profiling of the estrous cycle in wild house mice.

ABSTRACT: Symbiotic microbial communities affect the host immune system and produce molecules contributing to the odor of an individual. In many mammalian species, saliva and vaginal fluids are important sources of chemical signals that originate from bacterial metabolism and may act as honest signals of health and reproductive status. In this study, we aimed to define oral and vaginal microbiomes and their dynamics throughout the estrous cycle in wild house mice. In addition, we analyzed a subset of vaginal proteomes and metabolomes to detect potential interactions with microbiomes. 16S rRNA sequencing revealed that both saliva and vagina are dominated by Firmicutes and Proteobacteria but differ at the genus level. The oral microbiome is more stable during the estrous cycle and most a

SUBMITTER: Matejkova T 

PROVIDER: S-EPMC10846187 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature