Stability of meropenem in portable elastomeric infusion devices: which protocol should be implemented in clinical practice?

ABSTRACT: Meropenem has an excellent activity against gram-positive and gram-negative bacteria, including multi-resistant microorganisms. Even though meropenem is a great candidate for outpatient parenteral antimicrobial therapy (OPAT), its physicochemical stability is a major challenge. This work aimed to demonstrate the suitability of including meropenem in OPAT by elucidating its physicochemical stability in a range of commonly prescribed concentrations within portable elastomeric infusion devices. Physical and chemical stability were evaluated at two concentrations commonly used in clinical practice (2 and 25 mg/mL), and three temperatures (2°C-8°C, 25°C, and 32°C) using Accufuser portable elastomeric infusion devices. Drug adsorption onto portable elastomeric infusion devices was also determine

SUBMITTER: Esteban-Cartelle B 

PROVIDER: S-EPMC10846201 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature