Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergence.

ABSTRACT: Mycobacterium abscessus pulmonary disease is increasing in prevalence globally, particularly for individuals with cystic fibrosis. These infections are challenging to treat due to a high rate of resistance. Amikacin is critical to treatment, but the development of toxicity, amikacin resistance, and treatment failure are significant challenges. Amikacin has been characterized previously as peak-dependent and extended-interval dosing is commonly used. In our hollow fiber infection model of M. abscessus, amikacin exhibited time-dependent rather than the expected peak-dependent pharmacodynamics. Humanized amikacin exposures with more frequent, short-interval dosing (continuous infusion or every 12 hours) yielded improved microbiological response compared to extended-interval dosi

SUBMITTER: Gibson JE 

PROVIDER: S-EPMC10846206 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature