Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus.

ABSTRACT: The adaptive arm of the immune system is crucial for appropriate antitumor immune responses. It is generally accepted that clusters of differentiation 4⁺ (CD4⁺) T cells, which mediate T helper (Th) 1 immunity (type 1 immunity), are the primary Th cell subtype associated with tumor elimination. In this review, we discuss evidence showing that antitumor immunity and better prognosis can be associated with distinct Th cell subtypes in experimental mouse models and humans, with a focus on Th2 cells. The aim of this review is to provide an overview and understanding of the mechanisms associated with different tumor outcomes in the face of immune responses by focusing on the (1) site of tumor development, (2) tumor properties (i. e., tumor metabolism and cytokine receptor e

SUBMITTER: Silva RCMC 

PROVIDER: S-EPMC10846313 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature