MiR-338-3p acts as a tumor suppressor in lung squamous cell carcinoma by targeting FGFR2/FRS2.

ABSTRACT:

Background

Lung cancer refers to the occurrence of malignant tumors in the lung, and squamous cell carcinoma is one of the most common pathological types of non-small cell lung cancer. Studies have shown that microRNAs (miRNAs) play an important role in the occurrence, development, early diagnosis, and treatment of lung cancer. This study aimed to explore the role and possible mechanism of MicroRNA-338-3p (miR-338-3p) in lung squamous cell carcinoma (LUSC).

Method

In this study, we compared 238 LUSC patients with relatively high miR-338-3p expression levels with 238 miR-338-3p expression levels in The Cancer Genome Atlas (TCGA)-LUSC dataset using first-line gene set enrichment analysis (GSEA). Second, the mRNA expression of miR-338-3p, FGFR2, and fibroblast growth fac

SUBMITTER: Shan X 

PROVIDER: S-EPMC10846316 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature