Incidence rate and treatment strategy of immune checkpoint inhibitor mediated hepatotoxicity: A systematic review.

ABSTRACT:

Background

A hepatic adverse event (HAE) is defined as a liver injury that occurs following immune checkpoint inhibitor (ICI) administration in oncology Patients. Immune-mediated hepatotoxicity (IMH) is a type of HAE directly caused by ICI and is associated with immune system hyperactivation. HAE incidence varies across different clinical studies. This study aimed to explore the risk factors of HAE and establish a personalized IMH treatment strategy.

Methods

Randomized controlled trials (RCTs) on ICIs and case reports related to IMH were collected and summarized separately. Meta-analysis was performed using Review Manager (version 5.0), whereas correlation analysis and linear regression were performed using SPSS (version 24.0) to evaluate any correlations between the two var

SUBMITTER: Miao K 

PROVIDER: S-EPMC10846339 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature