RPE Curvature Can Screen for Early and Intermediate AMD.

ABSTRACT:

Purpose

Diagnosing AMD early optimizes clinical management. However, current diagnostic accuracy is limited by the subjectivity of qualitative diagnostic measures used in clinical practice. This study tests if RPE curvature could be an accurate, quantitative measure for AMD diagnosis.

Methods

Consecutive patients without AMD or normal aging changes (n = 111), with normal aging changes (n = 107), early AMD (n = 102) and intermediate AMD (n = 114) were recruited. RPE curvature was calculated based on the sinuosity method of measuring river curvature in environmental science. RPE and Bruch's membrane were manually segmented from optical coherence tomography B-scans and then their lengths automatically extracted using customized MATLAB code. RPE sinuosity was calculated as a rat

SUBMITTER: Cheung R 

PROVIDER: S-EPMC10846343 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature