Anxiety Change After Dopamine Therapy in Parkinson Disease is Independent of Motor Improvement.

ABSTRACT:

Background

Several anxiety syndromes have been associated with Parkinson disease (PD), but their interactions with dopamine replacement therapy (DRT) and motor function dynamics are not completely understood. We sought to delineate how DRT impacts anxiety phenomenology in PD and whether these changes are dissociable from improved motoric function.

Methods

We compared anxiety responses to DRT in two cohorts: 1) a study of 200 PD participants who completed neuropsychiatric assessments before and after taking their dopaminergic medications ("On-Off"); 2) participants in the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort who completed the State-Trait Anxiety Inventory (STAI) at the time of DRT initiation and a subsequent study visit (n = 113, mean 8-month in

SUBMITTER: Hinkle JT 

PROVIDER: S-EPMC10846408 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature