Simulating photodynamic therapy for the treatment of glioblastoma using Monte Carlo radiative transport.

ABSTRACT:

Significance

Glioblastoma (GBM) is a rare but deadly form of brain tumor with a low median survival rate of 14.6 months, due to its resistance to treatment. An independent simulation of the INtraoperative photoDYnamic therapy for GliOblastoma (INDYGO) trial, a clinical trial aiming to treat the GBM resection cavity with photodynamic therapy (PDT) via a laser coupled balloon device, is demonstrated.

Aim

To develop a framework providing increased understanding for the PDT treatment, its parameters, and their impact on the clinical outcome.

Approach

We use Monte Carlo radiative transport techniques within a computational brain model containing a GBM to simulate light path and PDT effects. Treatment parameters (laser power, photosensitizer concentration, and irradiation t

SUBMITTER: Finlayson L 

PROVIDER: S-EPMC10846422 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature