Iridium-catalysed hydroamination of internal homoallylic amines.

ABSTRACT: An Ir-catalysed regioselective hydroamination of internal homoallylic amines is reported. Both cyclic and acyclic internal olefins undergo directed hydroamination reactions with both aromatic and cyclic aliphatic amines to afford a variety of 1,4-diamines in fair to excellent yields. Diastereoselectivity and mechanistic investigations support that for cyclic substrates the reactions are proceeding via trans-aminoiridation to form a 5-membered metalacyclic intermediate.

SUBMITTER: Ho AT 

PROVIDER: S-EPMC10846566 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature