Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control.

ABSTRACT: Influenza A virus (IAV) can cause severe respiratory infection leading to significant global morbidity and mortality through seasonal epidemics. Likewise, the constantly increasing number of cancer diseases is a growing problem. Nevertheless, the understanding of the mutual interactions of the immune responses between cancer and infection is still very vague. Therefore, it is important to understand the immunological cross talk between cancer and IAV infection. In several preclinical mouse models of cancer, including melanoma and colorectal cancer, we observed that IAV infection in the lung significantly decreased the tumour burden. Concomitantly, tumour-specific CD8+ T-cells are strongly activated upon infection, both in the tumour tissue and in the lung. CD8+ T-cell depletion during infe

SUBMITTER: Steinbach P 

PROVIDER: S-EPMC10846710 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature