The genome formula of a multipartite virus is regulated both at the individual segment and the segment group levels.

ABSTRACT: Differential accumulation of the distinct genome segments is a common feature of viruses with segmented genomes. The reproducible and specific pattern of genome segment accumulation within the host is referred to as the "genome formula". There is speculation and some experimental support for a functional role of the genome formula by modulating gene expression through copy number variations. However, the mechanisms of genome formula regulation have not yet been identified. In this study, we investigated whether the genome formula of the octopartite nanovirus faba bean necrotic stunt virus (FBNSV) is regulated by processes acting at the individual segment vs. viral population levels. We used a leaf infiltration system to show that the two most accumulated genome segments of the FBNSV posses

SUBMITTER: Bonnamy M 

PROVIDER: S-EPMC10846721 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature