Association of Perioperative Antibiotics with the Prevention of Postoperative Fistula after Cleft Palate Repair.

ABSTRACT:

Background

There is debate amongst surgeons regarding the use of antibiotics to prevent fistulae after palatoplasty. Prescribing should be evidence based, as antibiotic stewardship is integral to reducing antibiotic resistance. Our aim was to determine whether differing perioperative regimens affect the prevalence of postoperative fistulae.

Methods

The sample comprised participants from the Cleft Collective who had undergone palatoplasty. Participants were recruited across all 16 UK cleft centers between 2013 and 2021. The exposure was perioperative antibiotic regimen prescribed at the time of palatoplasty. The primary outcome was the presence of palatal fistula.

Results

Fistula data were available for 167 participants when exploring antibiotic regimen and for 159 whe

SUBMITTER: Davies A 

PROVIDER: S-EPMC10846777 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature