Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms.

ABSTRACT: Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal feature of aging and mitochondrial diseases, and cells closely monitor membrane potential as an indicator of mitochondrial health. Given its central importance, it is logical that cells would modulate mitochondrial membrane potential in response to demand and environmental cues, but there has been little exploration of this question. We report that loss of the Sit4 protein phosphatase in yeast increases mitochondrial membrane potential, both by inducing the electron transport chain and the phosphate starvation response. Indeed, a similarly elevated mitochondrial membrane potential is also elicited

SUBMITTER: Ouyang Y 

PROVIDER: S-EPMC10846858 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature