How to obtain the image-derived blood concentration from ⁸⁹Zr-immuno-PET scans.

ABSTRACT:

Background

PET scans using zirconium-89 labelled monoclonal antibodies (⁸⁹Zr-mAbs), known as ⁸⁹Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of ⁸⁹Zr-mAbs in the blood. Measuring activity concentrations in blood, however, requires invasive blood sampling. This study aims to identify the best delineation strategy to obtain the image-derived blood concentration (IDBC) from ⁸⁹Zr-immuno-PET scans.

Methods

PET imaging and blood sampling of two ⁸⁹Zr-mAbs were included, ⁸⁹Zr-cetuximab and ⁸⁹Zr-durvalumab. For seven patients receiving ⁸⁹Zr-cetuximab, PET scans on 1-2 h, 2 and 6 days post-injection (p.i.) were analysed. Five patients received

SUBMITTER: Wijngaarden JE 

PROVIDER: S-EPMC10847076 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature