Mi-BMSCs alleviate inflammation and fibrosis in CCl₄-and TAA-induced liver cirrhosis by inhibiting TGF-β/Smad signaling.

ABSTRACT: Cirrhosis is an aggressive disease, and over 80 % of liver cancer patients are complicated by cirrhosis, which lacks effective therapies. Transplantation of mesenchymal stem cells (MSCs) is a promising option for treating liver cirrhosis. However, this therapeutic approach is often challenged by the low homing ability and short survival time of transplanted MSCs in vivo. Therefore, a novel and efficient cell delivery system for MSCs is urgently required. This new system can effectively extend the persistence and duration of MSCs in vivo. In this study, we present novel porous microspheres with microfluidic electrospray technology for the encapsulation of bone marrow-derived MSCs (BMSCs) in the treatment of liver cirrhosis. Porous microspheres loaded with BMSCs (Mi-BMSCs) exhi

SUBMITTER: Shi Q 

PROVIDER: S-EPMC10847164 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature