Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer's disease.

ABSTRACT: Synapse loss correlates with cognitive decline in Alzheimer's disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of understanding of how Aβ leads to synapse degeneration. In particular, there has been difficulty in determining whether there is a synaptic receptor that binds Aβ and mediates toxicity. While many candidates have been observed in model systems, their relevance to human AD brain remains unknown. This is in part due to methodological limitations preventing visualization of Aβ binding at individual synapses. To overcome this limitation, we combined two high resolution microscopy techniques: array tomography and Förster resonance energy transfer (FRET) to image over 1 million individual synaptic

SUBMITTER: Colom-Cadena M 

PROVIDER: S-EPMC10847197 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature