Gene variants for the WNT pathway are associated with severity in periodontal disease.

ABSTRACT:

Objective

Studies of Wnt variants-related to bone resorption in periodontitis are limited. The aim of this study was to establish the genotype and allele frequency of gene variants associated with the Wnt pathway in systemically healthy individuals with and without periodontitis (PD).

Materials and methods

One hundred fifty-seven systemically healthy individuals were evaluated, 90 with PD and 67 without PD. Periodontal clinical indexes, serological and clinical indices of inflammation, and the following variants associated with the Wnt pathway: DKK, SOST, LRP5, and KREMEN were analyzed by high resolution melting and confirmed by Sanger sequencing.

Results

In the PD-free group, 67.2% of the individuals presented the variant for DKKrs1896367 (p = 0.008) and 82.6% had th

SUBMITTER: Ospina-Ch MV 

PROVIDER: S-EPMC10847211 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature