Longitudinal faster anxiety progression of GBA variant carriers in the early Parkinson's disease cohort.

ABSTRACT:

Objective

Anxiety symptoms are prevalent neuropsychiatric manifestations in Parkinson's disease (PD) and impact the development of motor complications. Our aim was to evaluate the association of GBA variants with the anxiety development in early PD cohort.

Methods

This cohort study used data from the Parkinson Progression Marker Initiative. The primary outcome anxiety was assessed by State-Trait Anxiety Inventory (STAI). The association between GBA and longitudinal change in the STAI total score was examined using linear mixed-effects model, and the association between GBA and anxiety progression was examined using Cox survival analysis.

Results

A total of 385 patients with PD were included in this study, 39 of them were GBA variant carrier

SUBMITTER: Sang S 

PROVIDER: S-EPMC10847242 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature