An in vitro study of the effects of respiratory circuit setup and parameters on aerosol delivery during mechanical ventilation.

ABSTRACT:

Introduction

Aerosol therapy is often prescribed concurrently during invasive mechanical ventilation (IMV). This study determines the effects of nebuliser position, circuit humidification source, and most importantly, lung health on the delivery of aerosol in simulated adult and paediatric IMV patients. Furthermore, the influence of closed suction catheters on aerosol delivery is also addressed.

Methods

A vibrating mesh nebuliser was used to deliver Albuterol to simulated adult and paediatric IMV patients with differing states of lung health. Four different nebuliser positions and two types of humidification were analysed. Closed suction catheter mounts, a mainstay in IMV therapy, were incorporated into the circuits. The mean ± SD dose of aerosol (%) was assayed from a filte

SUBMITTER: Reilly L 

PROVIDER: S-EPMC10847248 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature