Genetics of psycho-emotional well-being: genome-wide association study and polygenic risk score analysis.

ABSTRACT:

Background

Psycho-emotional well-being is essential for living a life of satisfaction and fulfillment. However, depression and anxiety have become the leading mental health issues worldwide, according to the World Health Organization. Both disorders have been linked to stress and other psychological factors. Their genetic basis remains understudied.

Methods

In 2020-2021, the psycho-emotional well-being of 30,063 Russians with no known psychiatric history was assessed using the Hospital Anxiety and Depression Scale (HADS) for general mental health and the HADS subscale A (anxiety) for anxiety. Following the original instructions, an anxiety score of ≥11 points was used as the anxiety threshold. A genome-wide association study was performed to find associations between anxiety

SUBMITTER: Yakovchik AY 

PROVIDER: S-EPMC10847277 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature