Exploring the tumor micro-environment in primary and metastatic tumors of different ovarian cancer histotypes.

ABSTRACT: Ovarian cancer is a highly heterogeneous disease consisting of at least five different histological subtypes with varying clinical features, cells of origin, molecular composition, risk factors, and treatments. While most single-cell studies have focused on High grade serous ovarian cancer, a comprehensive landscape of the constituent cell types and their interactions within the tumor microenvironment are yet to be established in the different ovarian cancer histotypes. Further characterization of tumor progression, metastasis, and various histotypes are also needed to connect molecular signatures to pathological grading for personalized diagnosis and tailored treatment. In this study, we leveraged high-resolution single-cell RNA sequencing technology to elucidate the cellular compositions

SUBMITTER: Xie B 

PROVIDER: S-EPMC10847324 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature